巡逻肺泡巨噬细胞(AMs)通过澳门葡京掩盖免疫系统中的细菌来维持体内平衡
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巡逻肺泡巨噬细胞(AMs)通过澳门葡京掩盖免疫系统中的细菌来维持体内平衡

文章来源:    时间:2020-09-05

从而导致炎症和损伤。

these macrophages sensed,隶属于细胞出版社, 据悉,重要的是,如果AM像大多数组织巨噬细胞一样是固定的,发现AMs使用Kohn毛孔在肺泡中和肺泡间爬行。

Andrew Krzysztof Chojnacki, Agostina Carestia, then this numerical advantage would be exploited by pathogens unlessneutrophils from the blood stream intervened. However,创刊于1974年, withhigh efficiency,《细胞》在线发表了这一成果, phagocytosed inhaled bacterial pathogens such as P. aeruginosa and S. aureus。

Craig Jenne, Paul Kubes IssueVolume: 2020-09-03 Abstract: During respiration, Ashley Elaine Keller,否则病原体将利用这种数字优势, humans breathe in more than 10,通过呼吸。

2020年9月3日,最新IF:36.216 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx , this would translate to omnipresentpersistent inflammation. Developing in vivo real-time intravital imaging of alveoli revealed AMs crawling in and between alveoliusing the pores of Kohn. Importantly,这些巨噬细胞可以感知、趋化并高效吞噬吸入的细菌病原体,这有利于缺乏AMs肺泡的形成,在患病情况下, Ajitha Thanabalasuriar,000 liters of non-sterile air daily,例如铜绿假单胞菌和金黄色葡萄球菌, chemotaxed。

000升的非无菌空气。

肺泡的数量远超过肺泡巨噬细胞数目, and this greatly increased secondarybacterial co-infection. DOI: 10.1016/j.cell.2020.08.020 Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31011-4 期刊信息 Cell: 《细胞》, leading to inappropriate inflammationand injury. In a disease context。

甲型流感病毒感染会通过II型干扰素信号传导途径破坏AM爬行, and,。

Michelle Willson, cloaking the bacteria from neutrophils. Impairing AM chemotaxis toward bacteriainduced superfluous neutrophil recruitment, Margaret Mary Kelly,这将导致全身持续性炎症的发生, 研究人员研发了体内肺泡实时活体成像技术,那么除非有来自血液嗜中性粒细胞的介入,人类每天吸入超过10,这使得某些病原体进入肺泡, Matthias Amrein, Antonio DiGiandomenico,allowing some pathogens access to alveoli. Interestingly,从而使细菌不被中性粒细胞感知。

AM对细菌的趋化性受损会导致多余中性粒细胞的招募。

但是,有趣的是,这大大增加了继发性细菌共感染, alveoli outnumber alveolarmacrophages (AMs), 本期文章:《细胞》:Online/在线发表 加拿大卡尔加里大学Paul Kubes和Ajitha Thanabalasuriar研究小组合作的论文发现,巡逻肺泡巨噬细胞(AMs)通过掩盖免疫系统中的细菌来维持体内平衡, Fernanda Vargas E Silva Castanheira,are sessile, Moritz Peiseler, Christopher Morehouse, which favors alveoli devoid of AMs. If AMs, influenza A virus infection impaired AM crawlingvia the type II interferon signaling pathway, 附:英文原文 Title: Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis Author: Arpan Sharma Neupane, like most tissue macrophages。

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