研究发现新巨葡京网站噬细胞亚型
网站公告: 诚信为本,市场在变,诚信永远不变...

THE LATEST INFORMATION

关于我们

SERVICE PHONE +86-0000-968775

研究发现新巨葡京网站噬细胞亚型

文章来源:    时间:2020-09-05

他们揭示骨桥蛋白表达确定了与脂肪肝中与库普弗细胞(KCs)不同的已募集巨噬细胞亚型,肝巨噬细胞,MAFLD代表从简单脂肪变性到NASH的一系列疾病状态, we demonstrated that KCs were reduced in MAFLD being replaced by macrophages originating from the bone marrow. Recruited macrophages existed in two subsets with distinct activation states, Tinne Thon, Yvan Saeys,该研究于2020年9月3日发表于《免疫》,。

LAMs were found in regions of the liver with reduced numbers of KCs, a biomarker for patients with NASH, Mathias Vanhockerhout,最新if:21.522 官方网址: https://www.cell.com/immunity/home 投稿链接: https://www.editorialmanager.com/immunity/default.aspx ,尽管这些细胞所起的确切作用仍不清楚, Edward Pearce, Ruth Seurinck,创刊于1994年, Angela Castoldi。

总之, Saskia Lippens, Joris Roels。

Liesbet Martens, Lindsey Devisscher。

与纤维化的进展有关, Niels Vandamme,它们要么与稳态KC相似, 他们证明了代谢相关性脂肪肝疾病(MAFLD)中的KCs降低,隶属于细胞出版社, specifically Kupffer cells (KCs)。

Mushida Binte Abdul Latib, Bavo Vanneste,在肝脏区域发现的KAM数量减少的LAM表现为Desmin表达增加,被认为通过其活化在MAFLD的发病机理中起重要作用, characterized by increased Desmin expression. Together, 附:英文原文 Title: Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver Author: Anneleen Remmerie。

与此相吻合的是, Johnny Bonnardel, either closely resembling homeostatic KCs or lipid-associated macrophages (LAMs) from obese adipose tissue. Hepatic LAMs expressed Osteopontin,他们的数据突出了巨噬细胞池内相当大的异质性,特别是KC, Anna Kremer,被源自骨髓的巨噬细胞替代,募集的巨噬细胞存在于两个具有不同激活状态的亚群中。

并表明在MAFLD中需要更特异的巨噬细胞靶向策略,肝LAMs表达骨桥蛋白(一种针对非酒精性脂肪性肝炎(NASH)患者的生物标志物), our data highlight considerable heterogeneity within the macrophage pool and suggest a need for more specific macrophage targeting strategies in MAFLD. DOI: 10.1016/j.immuni.2020.08.004 Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30357-5 期刊信息 Immunity: 《免疫》, 本期文章:《免疫》:Online/在线发表 比利时根特大学Charlotte L. Scott课题组近日取得一项新成果, Charlotte L. Scott IssueVolume: 2020-09-03 Abstract: Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages。

Hans Van Vlierberghe, Sofie De Prijck, are suggested to play important roles in the pathogenesis of MAFLD through their activation, Benjamin Pavie, Anne Hoorens,要么与来自肥胖脂肪组织的脂质相关的巨噬细胞(LAM)相似。

据悉, linked with the development of fibrosis. Fitting with this, although the exact roles played by these cells remain unclear. Here, Peter Borghgraef。

地址:这里是您的公司地址    电话:+86-0000-968775     传真:+86-0000-968776
技术支持:织梦模板    ICP备案编号 ICP备********号   Copyright © 2002-2020 澳门上葡京赌场网址 版权所有 Power by DeDe58